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This Antimicrobial Prescribing and Stewardship Issue (volume 1) consist of manuscripts, including original research, review articles, case series, and opinion papers for topics related to antimicrobial (antibiotic, antifungal) stewardship, including: Disease-based/organism-based antimicrobial stewardship; Diagnostic stewardship; Influence of antimicrobial utilisation changes in antimicrobial resistance; Impact of antimicrobial stewardship on quality performance measures and patient outcomes; Novel antimicrobial stewardship education and training approaches or interventions aimed at the public and/or healthcare workers; Behavioural change approaches to antimicrobial stewardship; Collaborative practice agreements in antimicrobial stewardship; Antimicrobial stewardship in special populations (e.g., paediatrics, geriatrics, emergency medicine, hematology/oncology); Tackling AMR through antimicrobial stewardship in low- and middle-income countries; Antimicrobial stewardship for animal health; Antimicrobial stewardship in alternative settings (e.g., community practice, long-term care, and resource-limited small and rural hospitals); Antimicrobial use and stewardship in the context of the COVID-19 pandemic; Global collaborations to tackle AMR through antimicrobial stewardship.

Antibiotics. --- Anti-infective agents.

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Anti-infective agents.

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Anti-infective agents.

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Infectious microbial agents such as viruses, bacteria, fungi, and parasites can cause pathological disorders and even death in organisms exposed to the environment. However, organisms have an immune system to control infection caused by pathogens. The immune system is divided into the innate and the adaptive immune systems. The innate immune system is the first mechanism to respond to infections, whereas the adaptive immune system is based on immune memory. This book provides an overview of antiviral and antibacterial immune responses in different immune-reactive organs and across different animal species, from higher to lower vertebrates.

Anti-infective agents.

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For twenty years, the increase of resistances of the pathogens germs against the current anti-infective agents endangers the future of these therapeutic substances, which have their effectiveness reduced or even annihilated.For several decades, it has been found in animals some endogenous peptides containing anti-infective properties with structures completely different from classical molecules offering thereby new hope in the research of antibiotics.This dissertation aims to present the squalamine, an isolated steroid from the shark Squalus acanthias, and its various pharmacological properties (mainly anti-infective). Depuis une vingtaine d'année, l'accroissement des résistances des germes pathogènes face aux agents anti-infectieux actuels met en péril l'avenir de ces substances thérapeutiques, qui voient leur efficacité diminuée voir même annihilée.Depuis plusieurs dizaines d'années, il a été découvert chez les animaux des peptides endogènes possédant des propriétés anti-infectieuses avec des structures totalement différentes des molécules classiques offrant ainsi un nouvel espoir dans la recherche d'antibiotiques.Ce mémoire a pour but de présenter la squalamine, un stéroïde isolé du requin Squalus acanthias, et ses diverses propriétés pharmacologiques (anti-infectieuse principalement) .

squalamine --- Anti-Infective Agents